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Research
Our Mission
Intensive research in such areas as:
Nanomedicine – pharmaceutical nanocarriers with controllable properties for delivery and targeting of water-soluble and water-insoluble drugs, DNA, and diagnostic agents to various disease sites.
Intracellular drug delivery – the use of cell penetrating peptides for delivery of drugs and DNA directly into the cell cytoplasm bypassing the endocytic pathway and increasing the efficiency of therapies.
Experimental cancer immunotherapy – the research in the area of tumor- specific antibodies and the use of these antibodies for specific delivery of drugs and diagnostic agents to tumors.
Combination therapy of cancer – research in the area of combined cancer therapy involving physical methods, such as radiofrequency ablation or thermal ablation, and traditional chemotherapy with the use of pharmaceutical nanocarriers.
Novel imaging agents – engineering on new contrast agents for gammaimaging and magnetic resonance imaging of various pathologies including cancer by using a combination of disease-specific monoclonal antibodies and pharmaceutical nanocarriers.
Training domestic and international students, postdoctoral fellows, and visiting scientists for future academic, industrial, and medical studies.
Active collaboration with academic, medical, and industrial institutions in the Boston area, throughout the U.S., and abroad. Current collaborations within the U.S. include Harvard Medical School, Massachusetts General Hospital, Beth Israel Hospital, Tufts University, Auburn University, Louisiana Tech, and outside the U.S. We have collaborative projects with universities in Italy, Russia, Argentina, Turkey, Spain, Ireland, and Israel.
The NIH-funded Northeastern University Center for Translational Cancer Nanomedicine (CTCN) was established in September 2010 as part of Phase 2 of the National Cancer Institute’s Alliance for Nanotechnology in Cancer program with collaborators at Beth Israel Deaconess Hospital; Harvard Medical School; Tufts University, Auburn University and Nemucore Medical Innovations, Inc. The CTCN is utilizing the support and facilities of the NU-based Center for High-rate Nanomanufacturing. Northeastern University CTCN is one of nine Centers of Cancer Nanotechnology Excellence (CCNE) across the country that has been awarded a five-year $13.5 million grant from the NCI Alliance in an open nationwide competition. The Center is leading by Principal Investigator, Vladimir Torchilin, Ph.D., D.Sc, and Co-Principal Investigator, Nahum Goldberg, M.D. CTCN website
Domestic Collaborators:
Dr. Alexei Degterev, Department of Developmental, Molecular, and Chemical Biology,Tufts University, Boston, MA.
Dr. Valery Petrenko, Department of Pathobiology, Auburn University, Auburn, AL.
Dr. Dmitri Lapotko, Department of Biochemistry and Cell Biology, Rice University, Huston.
Dr. Yu. Lvov, Institute for Micromanufacturing, Louisiana Tech University, Ruston, LA.
Dr.Gabriel Lopez-Berestein, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD.
Dr. Ernst Lengyel, Department of Obstetrics/Gynecology, The University of Chicago Medicine, Chicago IL.
Dr. Muneeb Ahmed, Beth Israel Deaconess Medical Center, Boston, MA.
Dr. S. Nahum Goldberg, Beth Israel Deaconess Medical Center, Boston, MA.
Dr. Timothy Coleman, Nemucore Medical Innovations, Worcester, MA.
NU Collaborators:
Prof. Mansoor Amiji, Department of Pharmaceutical Sciences, School of Pharmacy.
Prof. Craig Ferris, Department of Pharmaceutical Sciences, School of Pharmacy.
Prof. Srinivas Sridhar, Department of Physics, College of Science.
Prof. Robert Hanson, Department of Chemistry and Chemical Biology, College of Science.
Prof. Ahmed Busnaina, Department of Mechanical and Industrial Engineering, College of Engineering.
International Collaborators:
Dr. Yael Mishael, Department of Soil and Water Sciences/Seagram Center, The Hebrew University, Rehovot, Israel.
Dr. Salvador Borrós i Gómez, Materials Engineering Group (GEMAT) Institut Químic de Sarrià-Universitat Ramon llull, Barcelona, Spain.
Dr. Lucas Antonio Miranda Ferreira, Pharmacy Faculty, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Dr. C. Tros de Ilarduya, Department of Pharmacy and Pharmaceutical Technology, University of Navarra, Pamplona, Spain.
Dr. Kitatani Kazuyuki, Tohoku University, Sendai, Japan.
Original website on archive.org:
https://web.archive.org/web/20240526191501/https://web.northeastern.edu/cpbn/research/
https://web.archive.org/web/20240526175711/https://web.northeastern.edu/cpbn/research/2/